Structural insight into allosteric inhibition of Mycobacterium tuberculosis tryptophan synthase
نویسندگان
چکیده
منابع مشابه
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
New antibiotics with novel targets are greatly needed. Bacteria have numerous essential functions, but only a small fraction of such processes-primarily those involved in macromolecular synthesis-are inhibited by current drugs. Targeting metabolic enzymes has been the focus of recent interest, but effective inhibitors have been difficult to identify. We describe a synthetic azetidine derivative...
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Mycobacterium tuberculosis is the most successful pathogen of the present times.It operates via a very complex and indispensable cell wall that is responsible for the persistence and resistance of the bacteria inside the human host. Various kind of lipids are present in mycobacterial cell wall, some unique to Mycobacteriumtuberculosis and some present evenly in other mycobacteria as well. Since...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2017
ISSN: 2053-2733
DOI: 10.1107/s0108767317095824